赖新生 博士，助理研究员

JDB电子生命科学研究院突触发育与可塑性研究室

邮箱：laixinsheng@ncu.edu.cn

教育经历：

1、2006-2013：西北农林科技大学，博士学位

2、2002-2006：西北农林科技大学，学士学位

工作经历：

1、2014至今：JDB电子生命科学研究院，助理研究员

2、2013-2014：浙江大学，博士后

3、2011-2012：美国Purdue University，访问学者

主要研究方向：

肌肉萎缩与神经肌肉接头功能障碍

承担的科研项目及经费：

在研：

1、2017年01月-2019年12月 国家自然科学基金青年项目 “LRP4在DMD肌肉再生障碍中的作用及分子机制” （81601092）17万元

2、2017年01月-2020年12月 国家自然科学基金地区科学基金项目 “COL6蛋白调控神经肌肉接头维持与老化的分子机制” （31660268） 38万元

主要发表文章：

1、Liu, W., Wen, Y., Bi, P., Lai, X., Liu, X.S., Liu, X. and Kuang, S. (2012) Hypoxia promotes satellite cell self-renewal and enhances the efficiency of myoblast transplantation. Development, 139, 2857-2865.

2、Liu, W., Liu, Y., Lai, X. and Kuang, S. (2012) Intramuscular adipose is derived from a non-Pax3 lineage and required for efficient regeneration of skeletal muscles. Dev Biol, 361, 27-38.

3、Yong-Zhen Huang, Liang-Zhi Zhang, Xin-Sheng Lai, Ming-Xun Li, Yu-Jia Sun, Cong-Jun Li, Xian-Yong Lan, Chu-Zhao Lei, Chun-Lei Zhang, Xin Zhao & Hong Chen*. Transcription Factor ZBED6 Mediates IGF2 Gene Expression by Regulating Promoter Activity and DNA Methylation in Myoblasts. Scientific Reports，2014，4 : 4570.

4、Lai, X., Zhang, C., Wang, J., Wang, C., Lan, X.Y., Lei, C.Z. and Chen, H. (2013) mRNA expression pattern and association study with growth traits of bovine vaspin gene. Mol Biol Rep , 40, 4499-4505.

5、Lai, X., Zhang, C., Wang, J., Wang, C., Lan, X.Y., Lei, C.Z. and Chen, H. (2013) Developmental expression patterns and association study with growth traits of bovine Bhlhe40 gene. Molecular Biology, 47, 674-680..

6、Lai, X., Lan, X., Chen, H., Wang, X., Wang, K., Wang, M., Yu, H. and Zhao, M. (2009) A novel SNP of the Hesx1 gene in bovine and its associations with average daily gain. Mol Biol Rep, 36, 1677-1681.

7、Wang, M*., Lai, X.*, Yu, H., Wang, J., Chen, Z.Q., Lan, X.Y., Lei, C.Z. and Chen, H. (2010) Two novel single nucleotide polymorphisms (SNPs) and 4-bp deletion mutation of RBP4 gene in Chinese cattle. J Genet, 89, 233-236.(* Co-first Author )

8、Mingxun Li, Xiaomei Sun, Liushuai Hua, Xinsheng Lai, Xianyong Lan, Chuzhao Lei, Chunlei Zhang, Xinglei Qi，Hong Chen*. SIRT1 gene polymorphisms are associated with growth traits in Nanyang cattle. Molecular and Cellular Probes, 2013, 27(7-8): 215-220.

9、Liangzhi Zhang, Mijie Li, Xinsheng Lai, Mingjuan Yang, Yao Xu, Liushuai Hua, Xianyong Lan, Chunlei Zhang, Hong Chen*. Haplotype combination of polymorphisms in the ADIPOQ gene promoter is associated with growth traits in Qinchuan cattle. Genome, 2013, 56(7): 389-394

10、Xianyong Lan, Xinsheng Lai, Zhuanjian Li, Jing Wang, Chuzhao Lei and Hong Chen*. Effects of genetic variability of the carpine homeobox transcription factor HESX1 gene on performance traits. Mol Biol Rep, 2010, 37(1): 441-449